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    **Authors’ contributions**

    LG designed and performed the research, prepared the figure and wrote the paper. GZ and ZB performed the research.

    This study was sponsored by National Natural Science Foundation of China (No. 81471184), National Natural Science Foundation of China (No. 81000165), Jiangsu Province Science Foundation for Youths (No. BK2012070), Jiangsu Province Medical Innovation Team (No. CXTDA201604), Jiangsu Province Six Talent Peaks Project (No. 2016-WSN-114), the Priority Academic Program Development of Jiangsu Higher Education Institutions (JX10231801), Jiangsu Province Key Medical Discipline (No. ZDXKA2016005) and Jiangsu Province Natural Science Foundation (No. BK2011361).

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