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Ankur Arora Murder Case Movie Trailer & Plot:.The effect of bioactive scaffold on hepatocyte proliferation and albumin production.
A bioactive scaffold can enhance hepatocyte proliferation and albumin production. The current study was performed to evaluate the effect of the porcine collagen-chitosan scaffold on hepatocyte proliferation and albumin production in vitro. Porcine collagen and chitosan were extracted from the pig’s skin and lung, respectively. Both porcine collagen and chitosan were cross-linked with glutaraldehyde. To examine the effect of the bioactive scaffold on hepatocyte proliferation, 2-3 mg of porcine collagen-chitosan scaffold was inserted into a 24-well plate and then seeded with L-02 cells at a density of 4×10(5) cells/well. The total DNA of each well was determined at days 1, 3, 5, and 7. To evaluate the effect of the bioactive scaffold on hepatocyte albumin production, the total protein level of each well was determined at days 0, 1, 2, 3, 5, and 7. The level of albumin was determined by ELISA. The porous structure of the bioactive scaffold can be fabricated by a specific program and also can enhance hepatocyte proliferation and albumin production. The bioactive scaffold has a potential application for the tissue engineering of liver in future.Absence of doxycycline-induced aplastic anemia in mice.
During the course of a study designed to develop an in vivo model for human acquired aplastic anemia, we investigated the potential for doxycycline-induced bone marrow failure in mice. In contrast to previous reports in the rat and ferret, we did not observe evidence of myelosuppression or other cytotoxic effects in mice at doses comparable to those used in humans. Doxycycline-induced hematopoietic toxicity was also not observed in a nonhuman primate. These results, in conjunction with those of our prior studies, suggest that doxy

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