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MediaChance.Multimedia.Builder.v4.9.8.7 Serial Key MediaChance.Multimedia.Builder.v4.9.8.7 Serial Key MediaChance.Multimedia.Builder.v4.9.8.7 Serial Key MediaChance.Multimedia.Builder.v4.9.8.7 Serial Key MediaChance.Multimedia.Builder.v4.9.8.7 Serial Key [MediaChance.Multimedia.Builder.v4.9.8.7] ., is currently under-described regarding the development of regenerative therapies for repair of the CNS. During MSC-based therapy for neurodegenerative disease, MSCs are known to be delivered directly into the brain parenchyma. In the case of Parkinson’s disease, evidence exists that delivery of MSCs into the SN can provide neuroprotective effects (Feng et al., 2006). In Parkinson’s disease, the phenomenon of engraftment is believed to be associated with the secretion of trophic factors that could influence the pathological degeneration and repair processes of neural cells. While the exact mechanisms have yet to be clearly elucidated, the trophic factors released during MSC-based therapies could potentially influence cell growth and survival in the damaged target tissue. However, this highlights a potential limitation in the use of the MSCs derived from adult tissues, which is the presumed difficulty in their migration to the damaged areas. The delivery of MSCs into the CNS has been shown to induce an immune response after transplantation, which could potentially mediate the adverse side effects of cellular therapy. Preclinical studies in ischemic stroke have demonstrated a reduced infarct volume and a reduced immune response compared to control groups (Oh et al., 2008). The adverse immune response following transplantation of MSCs limits their use as an effective therapeutic approach. The effect of parenchymal transplantation of MSCs requires further study and research. Several pre-clinical studies have demonstrated the potential benefit of MSCs for stroke and spinal cord injury repair (Lee et al., 2008; Qiu et al., 2008; Kocaeli et al., 2009; Sheng et al., 2012). Multiple mechanisms, including their anti-inflammatory properties, angiogenic potential, immunomodulatory effects, and trophic factor secretion, are believed to play a role in the observed effect (De Coppi

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